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127 results

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Page 1
Contribution of rare inherited and de novo variants in 2,871 congenital heart disease probands.
Jin SC, Homsy J, Zaidi S, Lu Q, Morton S, DePalma SR, Zeng X, Qi H, Chang W, Sierant MC, Hung WC, Haider S, Zhang J, Knight J, Bjornson RD, Castaldi C, Tikhonoa IR, Bilguvar K, Mane SM, Sanders SJ, Mital S, Russell MW, Gaynor JW, Deanfield J, Giardini A, Porter GA Jr, Srivastava D, Lo CW, Shen Y, Watkins WS, Yandell M, Yost HJ, Tristani-Firouzi M, Newburger JW, Roberts AE, Kim R, Zhao H, Kaltman JR, Goldmuntz E, Chung WK, Seidman JG, Gelb BD, Seidman CE, Lifton RP, Brueckner M. Jin SC, et al. Nat Genet. 2017 Nov;49(11):1593-1601. doi: 10.1038/ng.3970. Epub 2017 Oct 9. Nat Genet. 2017. PMID: 28991257 Free PMC article.
Congenital heart disease (CHD) is the leading cause of mortality from birth defects. ...
Congenital heart disease (CHD) is the leading cause of mortality from birth defects. ...
VEGF-C/VEGFR-3 axis protects against pressure-overload induced cardiac dysfunction through regulation of lymphangiogenesis.
Lin QY, Zhang YL, Bai J, Liu JQ, Li HH. Lin QY, et al. Clin Transl Med. 2021 Mar;11(3):e374. doi: 10.1002/ctm2.374. Clin Transl Med. 2021. PMID: 33783987 Free PMC article.
Prolonged pressure overload triggers cardiac hypertrophy and frequently leads to heart failure (HF). Vascular endothelial growth factor-C (VEGF-C) and its receptor VEGFR-3 are components of the central pathway for lymphatic vessel …
Prolonged pressure overload triggers cardiac hypertrophy and frequently leads to heart failure (HF). Vascular endothelial …
Lymphangiogenesis contributes to exercise-induced physiological cardiac growth.
Bei Y, Huang Z, Feng X, Li L, Wei M, Zhu Y, Liu S, Chen C, Yin M, Jiang H, Xiao J. Bei Y, et al. J Sport Health Sci. 2022 Jul;11(4):466-478. doi: 10.1016/j.jshs.2022.02.005. Epub 2022 Feb 23. J Sport Health Sci. 2022. PMID: 35218948 Free PMC article.
METHODS: Adult C57BL6/J mice were subjected to 3 weeks of swimming exercise to induce physiological cardiac growth. Oral treatment with vascular endothelial growth factor receptor 3 (VEGFR3) inhibitor SAR131675 was used to investig …
METHODS: Adult C57BL6/J mice were subjected to 3 weeks of swimming exercise to induce physiological cardiac growth. Oral treatment wi …
The Effect of Lymphangiogenesis in Transplant Arteriosclerosis.
Chen K, Mou R, Zhu P, Xu X, Wang H, Jiang L, Hu Y, Hu X, Ma L, Xiao Q, Xu Q. Chen K, et al. Circulation. 2023 Feb 7;147(6):482-497. doi: 10.1161/CIRCULATIONAHA.122.060799. Epub 2022 Dec 14. Circulation. 2023. PMID: 36515099
BACKGROUND: Transplant arteriosclerosis is a major complication in long-term survivors of heart transplantation. Increased lymph flow from donor heart to host lymph nodes has been reported to play a role in transplant arteriosclerosis, but how lymphangiogenesis affe …
BACKGROUND: Transplant arteriosclerosis is a major complication in long-term survivors of heart transplantation. Increased lymph flow …
VEGF-B Promotes Endocardium-Derived Coronary Vessel Development and Cardiac Regeneration.
Räsänen M, Sultan I, Paech J, Hemanthakumar KA, Yu W, He L, Tang J, Sun Y, Hlushchuk R, Huan X, Armstrong E, Khoma OZ, Mervaala E, Djonov V, Betsholtz C, Zhou B, Kivelä R, Alitalo K. Räsänen M, et al. Circulation. 2021 Jan 5;143(1):65-77. doi: 10.1161/CIRCULATIONAHA.120.050635. Epub 2020 Nov 18. Circulation. 2021. PMID: 33203221 Free article.
BACKGROUND: Recent discoveries have indicated that, in the developing heart, sinus venosus and endocardium provide major sources of endothelium for coronary vessel growth that supports the expanding myocardium. Here we set out to study the origin of the coronary ves …
BACKGROUND: Recent discoveries have indicated that, in the developing heart, sinus venosus and endocardium provide major sources of e …
VE-Cadherin Is Required for Cardiac Lymphatic Maintenance and Signaling.
Harris NR, Nielsen NR, Pawlak JB, Aghajanian A, Rangarajan K, Serafin DS, Farber G, Dy DM, Nelson-Maney NP, Xu W, Ratra D, Hurr SH, Qian L, Scallan JP, Caron KM. Harris NR, et al. Circ Res. 2022 Jan 7;130(1):5-23. doi: 10.1161/CIRCRESAHA.121.318852. Epub 2021 Nov 18. Circ Res. 2022. PMID: 34789016 Free PMC article.
BACKGROUND: The adherens protein VE-cadherin (vascular endothelial cadherin) has diverse roles in organ-specific lymphatic vessels. ...We sought to determine the spatiotemporal functions of VE-cadherin in cardiac lymphatics and mechanistically elucidate how VE-cadhe …
BACKGROUND: The adherens protein VE-cadherin (vascular endothelial cadherin) has diverse roles in organ-specific lymphatic ves …
The Role of the VEGF Family in Coronary Heart Disease.
Zhou Y, Zhu X, Cui H, Shi J, Yuan G, Shi S, Hu Y. Zhou Y, et al. Front Cardiovasc Med. 2021 Aug 24;8:738325. doi: 10.3389/fcvm.2021.738325. eCollection 2021. Front Cardiovasc Med. 2021. PMID: 34504884 Free PMC article. Review.
The vascular endothelial growth factor (VEGF) family, the regulator of blood and lymphatic vessels, is mostly investigated in the tumor and ophthalmic field. ...VEGF-C can regulate inflammation, lymphangiogenesis, angiogenesis, apoptosis, and fibrogene …
The vascular endothelial growth factor (VEGF) family, the regulator of blood and lymphatic vessels, is mostly in …
Functions and Regeneration of Mature Cardiac Lymphatic Vessels in Atherosclerosis, Myocardial Infarction, and Heart Failure.
Zhang Y, Bai Y, Jing Q, Qian J. Zhang Y, et al. Lymphat Res Biol. 2018 Dec;16(6):507-515. doi: 10.1089/lrb.2018.0023. Epub 2018 Oct 19. Lymphat Res Biol. 2018. PMID: 30339474 Review.
Besides, identification of specific lymphatic markers in recent decades paves the way for researches in development and regeneration of cardiac lymphatics, such as VEGF-C/VEGFR-3, EphB4/ephrin-B2, Prox-1, Podoplanin, and Lyve-1. Knocking out each of these markers in …
Besides, identification of specific lymphatic markers in recent decades paves the way for researches in development and regeneration of card …
Characterization of Prox1 and VEGFR-3 expression and lymphatic phenotype in normal organs of mice lacking p50 subunit of NF-kappaB.
Flister MJ, Volk LD, Ran S. Flister MJ, et al. Microcirculation. 2011 Feb;18(2):85-101. doi: 10.1111/j.1549-8719.2010.00057.x. Microcirculation. 2011. PMID: 21166921 Free PMC article.
RESULTS: Compared with WT, LVD in the liver and lungs of KO mice was reduced by 39% and 13%, respectively. This corresponded to 25-44% decreased VEGFR-3 and Prox1 expression. In the MFP, LVD was decreased by 18% but VEGFR-3 and Prox1 expression was 80- …
RESULTS: Compared with WT, LVD in the liver and lungs of KO mice was reduced by 39% and 13%, respectively. This corresponded to 25-44% decre …
127 results